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Phosphoinositide-3 kinases PI3Ks generate 3-phosphorylated phosphoinositide lipids that are implicated in many biological processes in homeostatic states and pathologies such as cancer, inflammation and autoimmunity. Following engagement of pathogen recognition receptors PRRsPI3Ks coordinate vital cellular sibgles of signaling and vesicular trafficking in innate phagocytes such as macrophages and professional antigen presenting dendritic cells DCs. Although previous studies demonstrated the involvement of PI3K isoforms in innate and adaptive immune cell types, the role of PI3Ks with Hot pink spa Drobak to DC biology has been enigmatic. PI3Ks are activated by diverse signaling pathways including small G proteins of Askoj and Rac family, tyrosine kinases- or G-protein- coupled receptors 1. Different classes of PI3Ks.

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